A once-a-day pill has shown promising results in rebuilding the bone structure in rodents suffering from severe osteoporosis, a new study finds.

Osteoporosis is a health condition in which the bones become fragile, porous and more vulnerable to fracture.

Previous studies had reported that the neurotransmitter serotonin, commonly known for its effects on mood, inhibits bone formation in the body.

According to the study published in Nature Medicine, blocking the production of serotonin in the gut with the experimental drug improves bone density and essentially cures osteoporosis in rats.

Known as LP533401, the oral drug was in fact made to treat irritable bowel syndrome (IBS) and has been tested in humans at high doses. Further studies, however, revealed its efficacy not only in reversing bone loss but also in building new bones in animals.
"This molecule is given once a day orally. Obviously it is very attractive. There are very few molecules that can induce bone formation," concluded lead researcher Gerard Karsenty.

The drug does not cross the blood-brain barrier and therefore does not interfere with serotonin's ability to stabilize mood.

Scientists are optimistic that their findings will pave the way for the development of more effective medication in treating the silent disease in humans.

PKH/HGH

Originally published in Press TV